The British royals are featured on the cover of the issue, which shows a seated Harry wearing all-black as he rests a protective hand on Meghan, who is dressed in a white shirt and matching trousers, while standing.
In a short essay about the pair, chef Jose Andres, who partnered with the couple last December (20) to build community centres with World Central Kitchen, wrote, "They turn compassion into boots on the ground through their Archewell Foundation. They give voice to the voiceless through media production."
"Hand in hand with nonprofit partners, they take risks to help communities in need - offering mental-health support to black women and girls in the U.S. and feeding those affected by natural disasters in India and the Caribbean."
He concluded, "In a world where everyone has an opinion about people they don't know, the duke and duchess have compassion for the people they don't know. They don't just opine. They run toward the struggle."
Elsewhere on the list, Olympian Simone Biles, Apple CEO Tim Cook, "Bridgerton" producer Shonda Rhimes, and music stars Timbaland and Swizz Beatz make the Titans section, while the Artists list features Puerto Rican singer Bad Bunny, rapper Lil Nas X, actress Scarlett Johansson, and more.
Billie Eilish tops the list of Pioneers while President Joe Biden and Vice President Kamala Harris are among those named as Leaders.