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The birthday girl received best wishes from fellow celebrities, like Ellen DeGeneres and Sofia Vergara, in addition to Vogue Magazine.
Witherspoon, who is a police officer, is protecting a drug dealer's wife played by Vergara, resulting in hilarious adventure.
Amy donned a white figure-hugging, floor-length gown, Reese flaunted her cleavage in a plunging purple long dress with a little train, while Felicity wore a black and lilac dress.
In addition to the threesome, Marion Cotillard and Meryl Streep have also been tapped as additional award presenters for the annual ceremony set to take place on Sunday, February 22.
Other celebrities who are also featured in the magazine include Benedict Cumberbatch, Eddie Redmayne, Felicity Jones, David Oyelowo, Sienna Miller, Oscar Isaac and Miles Teller.
Oprah looked fabulous in her knee-length purple dress, Reese sported a monochrome sleeveless gown, while Emma paired a striped top with a polka mid-length skirt.
Michael Keaton in Talks for 'Kong: Skull Island', Reese Witherspoon Joins Matt Damon in 'Downsizing'January 08, 2015 10:01:48
The 'Birdman' star is in talks to star in the movie alongside Tom Hiddleston, while the 'Wild' star is joining Damon in the Alexander Payne-directed movie.
Apart from the three stars, Robert Downey Jr., Brad Pitt, Eddie Redmayne, Rosamund Pike and Michael Keaton are among actors who are in attendance at the annual event.
The 'Legally Blonde' star creates the real-life 'Wreath Witherspoon' which is inspired by Mindy Kaling's homemade 'Wreath Witherspoon' creation on 'The Mindy Project'.
Shailene Woodley, Miles Teller, Steve Carell, Chadwick Boseman and David Oyelowo also take part in New York Times Magazine's Great Performers Issue which features nine kissing scenes.
Witherspoon reveals how her daughter reacted when she gave the teen a heads-up about her nude scene in the Cheryl Strayed biopic.
The 'Grace of Monaco' star and the 'Water for Elephants' actress will also produce the limited series based on Liane Moriarty's book.
The 38-year-old actress says the negative comments surrounding Renee's drastically changed appearance back in October are 'horrible.'
Emmy Rossum, who plays a caretaker of a woman with ALS in 'You're Not You, also joins Witherspoon, Zellweger and Katharine McPhee in the walk.
The 'Wild' actress talks about the next big step in her career as she attends Variety's Power of Women gala.