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Depp and his fiancee who both sport suits hold hands and are all smiles while posing on the red carpet at the event which is also attended by co-star Paul Bettany.
Charlie Mortdecai, an agent who's only armed with his good looks and charm, gets hit, loses a duel and causes explosion in the new trailer for the film set to hit theaters on January 23.
Depp admitted that he was dragged down by the pressure of scoring box office hits, describing it as 'being a dog at the track'.
Mike Myers calls Johnny Depp's slurred and expletive-laden introduction of best documentary winner 'very rock and roll.'
Depp's Mortdecai describes his wife as his only true love yet can't stand the charm of Olivia Munn's Georgina.
The 'Pirates of the Caribbean' actor and Die Antwoord's Ninja surprise the crowd at the Roxy in West Hollywood when they appear onstage while Manson sings his 'Beautiful People'.
Depp's character was previously seen only in a glimpse but the cover of EW magazine gives a full frontal look of the baddie.
Smith's daughter Harley Quinn Smith is also cast for the 'Tusk' follow-up which will center on two minor characters from the first film.
Based on a character created by Kyril Bonfiglioi, Charlie Mortdecai is an art dealer on a quest to recover a stolen painting.
The video gives a sneak peek at Meryl Streep channeling her inner witch, Johnny Depp unleashing his big bad wolf persona, and Anna Kendrick becoming a damsel in distress as Cinderella.
Chris Pine's Prince Charming, Mackenzie Mauzy's Rapunzel, Lilla Crawford's Red Riding Hood, and Meryl Streep's wicked Witch are also featured in the fresh stills.
De Niro is tapped to play opposite Robert Pattinson in the secretive thriller while Depp is in talks to portray the famed magician.
The 'Lone Ranger' actor undergoes dramatic transformation to play the infamous crime kingpin in the biopic directed by Scott Cooper.
When asked if he and her fiancee are expecting a child, the 'Pirates of the Caribbean' star says that their wedding is 'not a shotgun affair.'
The 'Pirates of the Caribbean' star confirms his engagement to Heard in an interview with 'Today' show, saying that Heard is 'a southern belle and sweet as can be, and very good for me.'