Sam (Jared Padalecki) and Dean (Jensen Ackles) meet Maggie Stark (guest star Charisma Carpenter), a witch who has unleashed her wrath on a small town, resulting in numerous deaths. Sam and Dean track down her husband, Donald (guest star James Marsters), to see if he can help. Donald tells the brothers that Maggie is mad at him for having an affair and is taking it out on the townspeople.