Picking up where the finale left off, Dean (Jensen Ackles) and Sam (Jared Padalecki) watch as the Devil (guest star Mark Pellegrino, "Lost") emerges from Hell. The brothers and Bobby (Jim Beaver) deal with the aftermath of Lucifer rising and the stunning news from Chuck the Prophet (guest star Rob Benedict) that Castiel (Misha Collins) was blown to bits by the archangels.