Dean (Jensen Ackles) and Sam (Jared Padalecki) are living very normal and separate lives.
Dean is a corporate man who enjoys health drinks and listens to news radio vs. rock stations. He works at a company called Sandover Bridge & Iron Company alongside Sam (Jared Padalecki) who is in Tech Support. It seems as if the two do not know each other.
However, after co-workers start committing suicide at an alarming rate, the two find themselves working side by side to solve the murders.