Sam (Jared Padalecki) and Dean (Jensen Ackles) capture a female vampire named Lucy (guest star Mercedes McNab) who claims to have no knowledge of how she became a vampire. The guys discover Dixon (guest star Matthew Humphreys), a male vampire, is giving out human blood to unsuspecting females in bars, offering it up as the "latest drug" and turning them all into vampires.

Meanwhile, Gordon (guest star Sterling K. Brown) escapes from jail and goes after Sam. However, Dixon intercepts Gordon and turns him into a vampire, which makes Gordon more powerful than before and a much bigger threat to Sam.