Michael Holt (Patrick Wilson) is a world-class neurosurgeon with his own modern, upscale practice in New York City. He lives to work, and his outward demeanor is cold and self absorbed. Everything changes for Michael when he runs into his ex-wife, Anna (Jennifer Ehle). What seems like an innocent meeting between two former lovers turns supernatural when he learns that Anna had been killed in a car accident two weeks earlier. As Michael struggles to fit the unexplainable into his scientific worldview, Anna comes to him again and asks him to help her close her loose ends on Earth. Specifically, the free clinic she had been running in a poor area of the Lower East Side has been turned upside down without her. As Michael reconnects with a woman that may only exist in his mind, a trip to the clinic reminds him that he can make a difference in the lives of many people - not just those with deep pockets.