The daytime talk show queen will be given the Minerva Award for her work in humanity through Angel Network.
TV titan Oprah Winfrey will be honored with a special award at the California Women's Conference in October. The talk show legend will be handed the Minerva Award by California's first lady Maria Shriver at the event, which celebrates powerful females who drive change in U.S. society.
Winfrey has been chosen by organizers of the conference for serving "on the frontlines of humanity", specifically for setting up her Leadership Academy for Girls in South Africa and her Angel Network charity.
The media mogul announced last month that she has closed down the Angel Network - which she set up in 1997 - as she prepares to step down from her "The Oprah Winfrey Show" in 2011.