The R&B legend, who has been blind from birth, overcame all the odds to become one of the most successful acts in music history, scoring a string of hits beginning with U.S. number one hit "Fingertips" in 1963 - making him the youngest artist ever to top the Billboard Hot 100 at just 13.
He went on to become a Motown legend, penning and performing classic tracks including "Superstition", "Uptight (Everything's Alright)", "For Once in My Life", and "I Was Made to Love Her".
As the star celebrated the milestone birthday on Wednesday, his famous pals came out in force early in the day to wish him an initial wave of birthday messages.
Among the first to pay tribute to the hitmaker was singer/actress Bette Midler who, ahead of the stroke of midnight, tweeted, "In five minutes, #StevieWonder will be 70 years young."
"Congratulations to a #NationalTreasure, and thank you for lighting up our lives for all these years," she added. "You are one of a kind, young man."
Singer Tevin Campbell wrote, "Genius was born and the world will always be blessed with it’s melody. Happy 70th Stevie," while writer/director Bree Newsome said, "I share a birthday with #StevieWonder Star-struck I've been proud ever since I first discovered this at 9 years old."
Actor Terry Crews added, "HAPPY BIRTHDAY STEVIE WONDER! We love you," alongside a sweet snap of the pair together along with wife Rebecca.
Meanwhile, the star has finally joined Instagram and a 24 hour marathon of his music played by DJs including Questlove, Britain's Gilles Peterson, Natasha Diggs, and DJ Spinna is being hosted on his new account @swfamily24 on Wednesday.