Sam (Jared Padalecki) is abducted by the Yellow-Eyed Demon and finds himself in a ghost town with other children who have special abilities. They learn the Demon has brought them together to initiate his endgame: an all-out war against the human race.In an effort to encourage Sam to fight, the Demon shows him what really happened to one of his parents.

Dean (Jensen Ackles) enlists Bobby's (guest star Jim Beaver) help to find Sam before the battle begins, but he arrives too late.