After Sam (Jared Padalecki) has a vision of Dean (Jensen Ackles) killing a young man who seems to be possessed by a demon, the two brothers head off to Oregon to search for answers.

They come across a town infected by a deadly virus that drives a person to kill. Sam becomes infected by one of the locals and prepares for his deadly fate, but after nothing happens to him, Dean decides to come clean and reveal what John (Jeffrey Dean Morgan) whispered to him before he died.