Friends of Derek and Addison's from NY come to Seattle but not for a social visit. The wife would like a preventative hysterectomy and mastectomy because she just discovered she has a gene that makes her susceptible to cancer in those regions. The wife wants the surgery, the husband thinks she's going too far, and the doctors including Izzie who's on the case are all in between. George nearly gets trampled by a window washer who falls from a high window.
The man survives because he lands on a pigeon, and is taken to the hospital. George thinks it's a miracle this guy survived, but the guy has a different take on things. Meredith and Bailey work with a couple where the wife finds out she has only a few months to live. She asks them not to tell her husband, but they already have and when told the news, the husband asks them not to tell the wife. They both want to protect the other from the news. Cristina and Burke go on a date, but it's not going so swimmingly at all until the date turns into a case when a fellow patron at the restaurant needs medical attention. It turns out to be the best date ever.