When Lucas (Chad Michael Murray) discovers that Derek's (guest star Matt Barr, "Commander in Chief") interest in Peyton (Hilarie Burton) is more than brotherly, Derek becomes menacing.Haley (Bethany Joy Galeotti) feels Nathan (James Lafferty) slipping away when he receives a scholarship offer to attend Duke University.As rumors of Brooke's (Sophia Bush) pregnancy spread, Rachel (Danneel Harris) uses the Internet to set Brooke up on a blind date with an older guy (guest star Reynaldo Valentin).

At Nathan's request, Deb (Barbara Alyn Woods) tries to kick her pill addiction.