Dr. Shaun Murphy, a young surgeon with autism and savant syndrome, continues to use his extraordinary medical gifts at St. Bonaventure Hospital's surgical unit. As his friendships deepen, Shaun continues to tackle the world of dating and romantic relationships and works harder than he ever has before, navigating his environment to prove to his colleagues that his talents as a surgeon will save lives.
In fourth season premiere, Dr. Murphy treats a patient who has an illness that is not only unpredictable in nature, but also unlike anything he or the team has seen before; Dr. Claire Brown continues to work through her grief, still reeling from Dr. Neil Melendez's death.