Based on November 6 episode of "" that features Dr. Izzie Stevens being reminded of her deceased fiance, Denny Duquette, which leads to a speculation of Izzie's brain tumor, Shonda Rimes finally gives her comment. To , she briefly says that the reason of bringing back Denny in the middle of Izzie and Alex has nothing to do with the deadly disease.
As Rimes states, "I think the love triangle with Denny, Izzie, and Alex is among the most interesting we've ever done. Watching the chemistry between Jeffrey and Katherine again has been really touching." Then she adds, "I can't wait for our viewers to see where we're taking it. But what it won't involve is Izzie having a brain tumor."