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The media mogul and philanthropist regains the top spot in the business magazine's Celebrity 100 list.
The Smithsonian's National Museum of African American History and Culture will name a 350-seat theater 'Oprah Winfrey Theater' to honor Oprah's generosity.
The OWN founder tells the students that they should strive to be 'the highest, most truthful expression of yourself as a human being,' adding, 'You want to max out your humanity.'
The Oklahoma-born crooner is one of many celebrities who have stepped up to help those affected by the disaster.
Shakira, Gisele Bundchen, Sofia Vergara, Hillary Clinton and First Lady Michelle Obama are also among the women who have made the most impact worldwide.
Winfrey reprises her Oscar-nominated role Sofia while Perry appears as Madea in the commercial to promote the premiere of two new scripted series on the cable channel.
Oprah defeats other popular celebrities, such as Steven Spielberg, Martin Scorsese, Ron Howard and George Lucas, to nab the first place on the annual list.
Gabrielle Union is also feted at the event, taking home Fierce and Fearless Award and delivering a heartfelt speech that brought many guests to tears.
Jay-Z's wife is joined by Oprah Winfrey on the red carpet of her film premiere at the Ziegfeld Theater in New York City.
'I've only seen [Oprah] nervous twice - Michael Jackson, back in the day that was live, and with Lance Armstrong,' Gayle says of what she saw in Oprah Winfrey before the much-talked-about interview.
The likes of Serena Williams, Lena Dunham, Rashida Jones and Rita Wilson give mixed responses to the cyclist's intense 'Oprah's Next chapter' interview.
The interview, in which the cyclist will reportedly admit his alleged doping scandal, is expanded to two-night event on OWN.
The 'Oprah's Next Chapter' interview which the cyclist first has since he lost his seven Tour de France titles is scheduled to air on January 17 in a special 90-minute episode.
The 'Oprah's Next Chapter' host falls for Ayana Mathis' debut novel, saying 'The opening pages of Ayana's debut took my breath away.'
The 'Liz and Dick' executive producer shares updates on his next project, saying that they are currently looking for writers for the TV movie about the former daytime talk show queen.