The 'Trainwreck' actress gets candid about the reason why her body seemed to reject Ozempic when she took the drug in an attempt to lose her unwanted fat.
- Jan 30, 2025
AceShowbiz - Amy Schumer opened up about her negative experience with Ozempic, sharing how a specific gene played a significant role in her inability to tolerate the medication.
Schumer, 43, began taking Ozempic - a medication initially used to treat type 2 diabetes - as a weight-loss aid almost three years ago. However, she was forced to discontinue the weekly injections due to severe nausea and vomiting.
Schumer later discovered that she carries the GDF15 gene, causing her body to produce abnormally low levels of the GDF15 hormone. This hormone, produced during pregnancy and by stressed organs or tumors, contributes to taste aversion, nausea, and vomiting.
"I was like bedridden," she shared, adding that she was left with "no energy" while taking the drug.
The comedian explained that her sensitivity to the GDF15 gene made Ozempic use almost impossible. "I lost 30 pounds so quick [on it]. I looked great, but I couldn't lift my head off the pillow, so what's the point?" she said.
Schumer criticized celebrities who promote the positives of Ozempic without acknowledging potential side effects and encouraged them to be transparent about their use of such medications.
"Everyone has been lying saying, 'Oh smaller portions.' Like shut the f*** up. You are on Ozempic or one of those things or you got work done. Just stop hiding it," she said.
Schumer's comments come days after she discussed how cruel comments about her "moon face" on social media led to her diagnosis of Cushing syndrome.
