✦Was voted as America's Sexiest TV Star by TV Guide thus graced the cover of the magazine's Sexiest Stars issue (May 2008).
✦Signed a deal with cosmetics giant Avon in March 2008 to be the face of the company's men's fragrance.
✦Made an appearance at the Central Maine Medical Center in Lewiston, Maine on March 10, 2008 to announce plans for a new cancer center to be named the Patrick Dempsey Center for Cancer Hope & Healing.
✦Named People Magazine's Star of the Year on December 20, 2007.
✦Signed as the new face of fashion house Versace in December 2007 to front the company's 2008 men's spring/summer line.