As news of Peyton's (Hilarie Burton) condition spreads, Mouth (Lee Norris) and Millicent (Lisa Goldstein) struggle to remain a couple and Brooke (Sophia Bush) tries to suss out Julian's (guest star Austin Nichols) intentions.

Peyton and Lucas (Chad Michael Murray) babysit Jamie (Jackson Brundage) and his friend, while Haley (Bethany Joy Galeotti) and Nathan (James Lafferty) spend a night out together.