Fast-talking New Yorker Zoe Hart (Rachel Bilson) has her life all figured out until she is turned down for a prestigious fellowship she had been certain she would get. Desperate, she decides to finally accept the offer of a kindly stranger, Dr. Harley Wilkes (guest star Nicholas Pryor), whom she met at her medical school graduation, and who had proposed she join his small medical practice in Bluebell, Alabama.