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The paranoia-fueled action thriller tops the chart with 19 million dollars, while 'The Lincoln Lawyer' and 'Paul' are racing to take the fourth position.
Hitting the red carpet solo, the lead actor was supported by Ed Helms and Ken Jeong when promoting his movie in Hollywood on Thursday.
Both snippets were unveiled only a few days before they are aired during Super Bowl XLV telecast this Sunday.
Cooper's character of a writer finds himself in danger after taking clear pill that makes him smarter, but has unpleasant side effects.
Cooper's Eddie Morra can 'access 100 percent of his brain, learn new languages and conquer Wall Street' after consuming the pill, which has brutal side effects.
After crouching down on the street side, the actor films a chasing scene on a New York street on the same day, April 1.