The "Trainwreck" actress appealed to followers for advice about undergoing in vitro fertilisation in a candid Instagram post on Thursday, January 9, when she shared a photo of her bare stomach, with bruise marks from the hormone injections used as part of the medical treatment.
In the accompanying caption, Schumer confessed she was feeling "really run down and emotional" after embarking on the lengthy process in a bid to give her eight-month-old son Gene, with her husband Chris Fischer, a sibling.
Selena was one of her first celebrity friends to comment on the news, writing, "I'm praying for you and chris. I'm sorry!".
Some sensitive critics were quick to jump on the remark, suggesting the singer was "sorry" they had turned to IVF, but Selena quickly returned to Instagram to expand on her short message and make it clear that wasn't what she had meant at all.
"let me clear that up," the 27-year-old added. "I said I'm sorry she's feeling that way. My mom went through the same thing. It's hard on women's heart (sic)."
Selena's mother, Mandy Teefey, welcomed daughter Gracie with her second husband, Brian Teefey, in 2013, two years after suffering a miscarriage.