The 10 celebrities will move into a remote camp in Australia and fight to become King or Queen of the Jungle.
Reports suggest Jenner, 70, will be one of the highest-paid celebrities to ever take part in the show, with sources claiming she'll earn close to $643,000 (£500,000).
Caitlyn famously took part in the U.S. version of the reality show in 2003.
Confirming her participation, Jenner says, "I thought this would be a great opportunity to leave everything behind for three weeks. Last time, it was almost like a cleansing of the soul."
"Dealing with other people is by far the hardest thing. It's much more difficult than dealing with the most poisonous snakes in the world. That's easy - just stay away from them. You can't get away from the other people, and it will be a very different experience for me. Last time, I did it with a bunch of people from the States who I knew of. This time it's a bunch of people from the U.K. who I potentially won't know.
"But I love the British people and I am looking forward to making some new friends, new allies and getting through it all."