The Canadian rapper's "In My Feelings" has landed a ninth week at number one, taking his run of 2018 chart-toppers to 28 weeks.
That matches Usher's feat in 2004.
Drake has chalked up his 28 weeks on top with three hits - "In My Feelings", "God's Plan" and "Nice For What".
He also breaks a tie with Usher for the most career weeks at number one, with 48.
Meanwhile, Eminem debuts two songs in the new Billboard Hot 100 - "Lucky You", featuring Joyner Lucas enters at six, while "The Ringer" jumps in at eight, giving the rapper his 18th and 19th top 10 hits and his first since "The Monster" hit number one in 2014.