(*): W=Win, N=Nomination
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2001 | W | Funniest Female Stand-Up Comic | - | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2007 | N | Best Voice Acting in an Animated Feature Production (As the voice of Stella) | Over the Hedge (2006) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2005 | W | Outstanding Supporting Actress in a Theatrical Film | Monster-in-Law (2005) | - |
| 2005 | N | Outstanding Lead Actress in a Comedy Series | Wanda at Large (2003) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2001 | N | Outstanding Writing for a Variety, Music or Comedy Program | The Chris Rock Show (1997) | Chris Rock, Tom Agna, Lance Crouther (writers) |
| 2000 | N | Outstanding Writing for a Variety, Music or Comedy Program | The Chris Rock Show (1997) | Chris Rock, Chuck Sklar, Mike Upchurch |
| 1999 | W | Outstanding Writing for a Variety or Music Program | The Chris Rock Show (1997) | Tom Agna, Vernon Chatman, Chris Rock |
| 1998 | N | Outstanding Writing for a Variety or Music Program | The Chris Rock Show (1997) | Chris Rock, Ali LeRoi, Steve O'Donnell |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2010 | W | - | - | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2016 | N | Outstanding Character Voice-Over Performance | Penn Zero (2014) (TV) | - |
| 2009 | N | Outstanding Supporting Actress in a Comedy Series | The New Adventures of Old Christine (2006) (TV) | - |
| 2006 | N | Outstanding Supporting Actress in a Comedy Series | Curb Your Enthusiasm (2000) | - |
| 2005 | N | Outstanding Supporting Actress in a Comedy Series | Curb Your Enthusiasm (2000) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2021 | N | The Comedy TV Star of 2021 | The Upshaws (2021) (TV) | - |
| 2019 | N | Comedy Act of 2019 | Wanda Sykes: Not Normal (2019) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2008 | N | Favorite Funny Female Star | - | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2018 | N | Outstanding Guest Actress in a Comedy Series | Black-ish (2014) (TV) | - |
| 2017 | N | Outstanding Guest Actress in a Comedy Series | Black-ish (TV) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2004 | N | Best Performance by an Actress in a Series, Comedy or Musical | Wanda at Large (2003) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2020 | N | Best in Comedy (Arts & Entertainment) | - | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2003 | N | Choice Comedian | - | - |
| 2003 | N | Choice TV Actress - Comedy | Wanda at Large (2003) | - |
| 2003 | N | Choice TV Breakout Star - Female | Wanda at Large (2003) | - |
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