Clark (Tom Welling) is exposed to silver kryptonite, causing him to have paranoid delusions. The silver kryptonite makes him believe that Chloe (Allison Mack) is going to reveal his secret, Jonathan (John Schneider) is scheming against him with Lionel (John Glover) and Lex (Michael Rosenbaum) and Lana (Kristin Kreuk) are having a secret relationship. Chloe and the Kents frantically search for a cure, but it is Professor Fine (guest star James Marsters) who comes to Clark's rescue - but not without an agenda.