A baby girl is born at Princeton-Plainsboro Hospital to Donald and Sarah Losinski. They are in the patient room with Donald's seven-year-old son, Walker. Donald goes to get food from the cafeteria, and when he returns, the baby is not there.
Cuddy checks with Nurses Maldonado and Smits, who attended to Sarah in the maternity ward. The baby is not in the nursery. Cuddy lets Donald know that the baby's hospital bracelet has not triggered any alarms, so the girl is still in the building. Cuddy orders a lockdown of the hospital. Everyone must stop what they are doing and stay where they are.
Cameron comes to see Chase to get him to sign their divorce papers. He won't sign until they have a real conversation about their relationship. They are stuck together in a clinic room as the lockdown is announced. Although they are at first silent with each other, they are forced to to rehash their problems.
House tries to escape the lockdown and sneaks into a room occupied by a sleeping patient named Nash. The patient wakes up, despite being on morphine. House checks his chart; Nash has Ischemic cardiomyopathy and the drug is not reaching his stomach, causing nausea. Nash needed a heart transplant but has diabetes and did not take his medicine. He recognizes House, and says that he tried to get him to take his case.
Trapped in the cafeteria, Wilson and Thirteen try to combat boredom by playing truth or dare. She is an expert player, but refuses to divulge anything about her relationship with Foreman. Wilson dares her to show her breasts to Taub.