Suicide bomber Salman Ramadan Abedi murdered 22 people in the attack on May 22, 2017, and another 50 were left injured by the blast in the foyer of the venue as fans were making their way out of the concert.
The star has since opened up on her mental health struggles off the back of the attack, and has been treated for post-traumatic stress disorder (PTSD), meaning Eminem's lyrics referencing the incident on his surprise new album, "Music to Be Murdered by", did not go down well with her fans.
"But I plan to shout 'bombs away' on the game / Like I'm outside of an Ariana Grande concert waiting," he raps on the tune.
The track also features lyrics about Iraqi tyrant Saddam Hussein, references to the 9/11 attacks in the U.S., and murdered child beauty queen JonBenet Ramsay.
"And you backpedal that as a cowardly act / Like a Saudi attack when the towers collapse," he continues. "Look at how I'm behaving me, they want me gone away / They wanna JonBenet me, I'm unaccommodating."
Social media users slammed the 47-year-old hip-hop star for his insensitive choice in lyrics.
"Eminem is truly pathetic, a weedy, middle aged, rich white man who tries to be rebellious by comparing himself to an Islamic bomber," wrote one fan, while another said, "This is what he thinks of as cutting edge, when all he has to do is say white privilege theory is bulls**t to make the feathers fly."
A third fan added, "Get all the free publicity off the back of a suicide bomber you wanted? you low life bottom feeder! @Eminem . Here's hoping you never step foot in (Britain) #Eminem."
Eminem, real name Marshall Bruce Mathers III, previously referenced the Manchester bombing in a freestyle rap in 2018.