Cuoco has developed "The Flight Attendant", an adaptation of Chris Bohjalian's bestselling 2018 novel, and will star as Cassandra Bowden, who has to turn detective when she wakes up next to a dead body in a Dubai hotel bed and tries to piece together the mystery of the man's death.
The project has landed at WarnerMedia, an upcoming streaming service from Warner Bros. TV.
Cuoco will serve as an executive producer alongside TV mogul Greg Berlanti, among others.
"I love that Warner Bros. is my home away from home, and I couldn't be more excited to continue this incredibly collaborative and gratifying relationship," Kaley says. "They're stuck with me now!".
Her new deal with the studio bosses includes a talent agreement, linking her to other new TV projects, including the title role in Warners' upcoming animated series "Harley Quinn".
Cuoco played Penny in "The Big Bang Theory" from 2007 to earlier this year (May 2019).