In the middle of the night, a young woman named Frankie writes about her personal life in an online blog. Her boyfriend Taylor becomes angry when she tells the world about intimate details of their relationship. They argue. Their neighbor, Stuart, knocks on the door to complain about the noise and he notices bruises on Frankie's face. Assuming that Taylor had beaten her, Stuart calls the police.
The team discusses Frankie's case of coagulopathy. Thirteen suggests checking her apartment for toxins. She goes there with Taub, and Stuart the neighbor finds them. Stuart mentions that Frankie is composting trash, which attracts rats. He has to spread poison around the building but Frankie picks up the poison.
House tells Wilson that he plans to stay home and watch porn. Wilson invites him to join him in speed dating so that he can meet a real woman. House walks into the speed dating bar to find Wilson has brought Chase. House is annoyed because Chase has an advantage with his good looks. House bets that if Chase acts like a jerk, loses his accent and avoids mentioning that he is a doctor, Chase will still score. Chase attempts this charade, but gets more attention than House or Wilson.
While Frankie updates her blog in the patient room, she explains to Taub and Foreman that her blog's title resembles her "considered life" which is open to the public. As she uses the toilet, she notifies the doctors that her urine is brown, which means her kidneys are failing. The team suggests Hemolytic uremic syndrome, Gaucher's, Sjogrens and Haff diseases as possibilities. House thinks that Frankie has Haff disease and orders her to be treated with saline and mannitol.
House calls out to Wilson that his porn collection is missing. Wilson tells him that he returned it to the store because he wanted the place to be a porn-free zone, in case he brought a woman from speed dating home. Wilson visits House's office that evening. House went to get his DVDs back but one was missing and he found a copy of it. He plays it "Feral Pleasures," which features a college-aged Wilson. Wilson explains that his roommate made it for a film class and then later added another actor to make it into an adult film. Wilson's character says, "Be not afraid. The forest nymphs have taught me how to please a woman." He walks out of the office and bumps into Thirteen who says, "Be not afraid." This means that everybody knows.
Chase is reading Frankie's blog about all her fights with Taylor. He questions whether her lack of arousal had nothing to do with their fight, but is physical and the result of Sjogren's disease. Chase preps Frankie for a sialogram to X-ray her salivary glands. She mentions that she is a night owl and that she feels she knows people on the internet because they share their most intimate thoughts with each other. Frankie is uncomfortable lying on her back, which Chase thinks indicates heart valve issues. Tests conclude that Frankie's mitrial valve is nearly gone.