Players in a video game known as SavageScape battle ferocious creatures. After the game ends, the testers find their boss, Vince Pearson, claiming that his hands are on fire.
House walks into Cuddy's office and quits. Foreman wants to run the diagnostic department and Cuddy offers him a chance to do it. Foreman settles in to House's office.
Foreman discusses Vince's case with Taub and Thirteen. Foreman says to treat him for complex regional pain syndrome with a spinal stimulation. Vince has other ideas, having looked up his symptoms on the internet. He thinks he must have mercury poisoning and wants to be tested. Despite Foreman's orders, Thirteen and Taub perform the test for mercury and not the spinal stimulation.
House has therapy with Dr. Nolan, who instructs him to take up a hobby. He joins Wilson in a cooking class.
Foreman gives Vince news that his mercury test came out negative. Vince demands treatment for the mercury but Foreman challenges him. Taub and Thirteen administer the spinal stimulation, and it sets Vince's lungs full with fluid.
Taub and Thirteen report back to Foreman that Vince has a thickened left ventricle in his heart, which caused pulmonary edema. Taub speculates that cocaine could be the culprit. Foreman admits to Thirteen that he has been comparing himself to House. Taub and Thirteen go search Vince's office.
Cuddy visits House at Wilson's apartment. He is cooking with a Chinese classmate and they talk about Cuddy in Chinese. Cuddy wants to know if she is the reason that House left the hospital. He says no.
As Taub and Thirteen play SavageScape, she complains that Foreman told her that he made a dinner reservation rather than asking her. Thirteen realizes that Vince, in researching the birds in the video game, may have caught something avian. She tells the patient he may have an infection called psittacosis, and Vince informs her that he has had a three-hour erection.
The doctors implant a stint for the priapism. Thirteen suggests Vince has a brain tumor but Foreman overrules her with a diagnosis of Thrombocystosis. Taub agrees with Foreman. Thirteen and Foreman are arguing about the new dynamic in their relationship when they see strange doctors in the patient's room. Vince brought posted his symptoms on the internet and brought in the doctors to diagnose him. Before Foreman can kick them out, one suggests the possibility of a brain tumor. Thirteen tries to be diplomatic by saying that both Foreman's diagnosis and the other doctor's have merit.
In the middle of the night, House cooks up different versions of meat sauce. He makes Wilson taste them.
Foreman is angry that Thirteen did not completely back him up. The MRI comes out clean, so he orders her to treat Vince for Thrombocystosis. Thirteen complains to House. He tells her to give in to save their relationship. She tastes the egg dish he is preparing, and she is impressed.
House decides to give up cooking because his leg pain returns. He confides to Dr. Nolan that he is afraid of turning back to Vicodin. Later, House goes back to his apartment and finds a bottle of Vicodin.
Foreman apologizes to Thirteen and they make up. They rush to Vince because he has a new symptom of swollen lymph nodes. Foreman was wrong about Thrombocystosis and Vince offers a $25,000 reward for an answer online. The team is swamped by suggestions sent in from the public. Vince wants to be tested for amyloidosis. Foreman makes a deal with him.
Taub tells Foreman the test results show deposits in the renal endothelium consistent with amyloidosis. Foreman is discouraged and turns to Thirteen for support.
Wilson finds House feeling much better, which worries him. Wilson shares his concerns with Cuddy. He had House's urine tested and it came back clean because it was from a dog.
Vince wanders to the hospital lobby, hallucinating that he is in the world of the video game. Foreman approaches and finds him feverish. Thirteen and Foreman discuss the diagnosis while Vince is in a tub to reduce his fever. Thirteen wants to turn to the internet theories but Foreman thinks Vince has LCDD, which can be treated with chemotherapy.
Wilson and Cuddy confront House. To prove he is clean, he urinates in their presence.
Foreman has taken a shower and looks at his fingers in the locker room. He rushes to stop the chemo. Vince's fingers did not prune up after being in the bathtub for an hour. This is a symptom of Fabry's disease. Thirteen also came to this conclusion based on iodine mumps, which came from an internet suggestion.
Thirteen comes to see Foreman in House's office. He is angry, but he needs her love. He fires her instead.
House shows Dr. Nolan a check for $25,000 that he earned from solving Vince's case online. Nolan thinks it is best for House to return to diagnostic medicine in order to save him from his own addiction.