AceShowbiz - In a recent episode of the "MeSsy" podcast with co-host Jamie-Lynn Sigler, Christina Applegate discussed the profound impact Multiple Sclerosis (MS) has had on her life. Describing herself as feeling like "Humpty Dumpty," the "Dead to Me" star opened up about the physical and emotional toll of the disease.

"I have no muscles in my legs. … I look like Humpty Dumpty. Like, my little, tiny, weird legs and then my big, menopausal belly," Applegate shared. This vivid analogy underscores the drastic changes MS has wrought on her body and her daily life.

The 52-year-old actress detailed how her condition has curtailed her physical activities. "Everyone I know who wants to do something with me … they know it's not gonna be a hike in the hills. That's not gonna happen because I'm so not conditioned right now," she explained.

Activities that once seemed manageable are now fraught with challenges, leading her to issue disclaimers to friends about possible last-minute cancellations. "If I'm puking or can't walk, you think I'm gonna go to a restaurant or go do anything? No, I'm not gonna do that," she added.

Despite these setbacks, Applegate has found solace in her longstanding preference for staying at home. However, she acknowledges that accepting the current realities of her life post-diagnosis remains a work in progress.

"There's never like, 'Oh my God, I'm back to who I was before all this happened!' No. For me, no, that's never gonna happen in my entire life. I will never be the girl I was in 2020. I will never be that person again, and that's what I have to accept," she said.

Applegate's journey has been marked by candid disclosures about the grueling physical and mental effects of MS. She has shared experiences of falling over in the shower, significant weight gain, and severe depression.

In a harrowing admission, she revealed, "I'm in a depression right now, which I don't think I've felt that for years. Like a real, f**k-it-all depression where it's kind of scaring me, too, a little bit because it feels really fatalistic. I'm trapped in, like, this darkness right now that I haven't felt [in] like, I don't even know how long, probably 20-something years."

Applegate, known for her roles in "Married…with Children" and "Anchorman," has largely retreated from the public eye, save for a few appearances with her cane. Her openness about her struggle with MS shines a light on the resilience needed to navigate life with a chronic illness. Her story is a powerful reminder of the strength found in vulnerability and the importance of empathy and support for those facing similar battles.