The actors, who wed in October, 2010 and are parents to three-year-old daughter Charlie, announced the sad news in a statement to People.
"It's with heavy hearts that we have come to the mutual decision to separate at this time," it reads. "Our daughter is our primary concern and we remain committed to co-parenting her together. We ask that you please respect our family's privacy at this time".
Both Dave and Odette have a string of TV hits under their belts and they teamed up to play lovers in 2018 TV movie "No Sleep 'Til Christmas".