In a world terrorized by super-villains, one woman has developed the process to give superpowers to regular people. But when scientist Emily Stanton (Octavia Spencer) accidentally imbues her estranged best-friend (Melissa McCarthy) with incredible abilities, the two women must become the first superhero team. Now, it is up to Thunder Force to battle the super-powered Miscreants and save Chicago from the clutches of The King (Bobby Cannavale).