"Harper's Island" is about a group of family and friends who travel to a secluded island for a destination wedding. They've come to laugh... to love... and, though they don't know it... to die. As the wedding festivities begin, friendships are tested and secrets exposed as a murderer claims victims, one by one, transforming the wedding week of fun and celebration into a terrifying struggle for survival.

In every episode, someone is killed and every person is a suspect, from the wedding party to the island locals. By the end of the 13 episodes, all questions will be answered, the killer will be revealed and only a few will survive.