The stars and their pals took to the popular video conference app while in lockdown to mark Jonathan and Drew's 42nd birthdays, and appeared to have a blast dressing up as characters from the hit HBO series.
For the online gathering, "New Girl" star Zooey dressed as Queen Cersei Lamester - a play on Lena Headey's Cersei Lannister - while Jonathan was his own character inspired by the House of Stark - Snobb Snark.
"All is well in the kingdom this eve as we played a 'Game of Thrones' inspired Murder Mystery with friends and family. SO fun," the "Property Brothers" star wrote alongside screenshots from the call.
"Thank you @zooeydeschanel for setting it all up. You're the best."