The "Mary Poppins Returns" star is in talks to lead the cast as author Rebecca Alexander, whose inspiring 2015 book chronicled her battle with rare genetic disorder Usher syndrome, which caused her to simultaneously begin to lose her hearing and sight from the time she was a teenager.
Despite her disabilities, she has pressed on with her work as a psychotherapist and group fitness instructor, and has continued to pursue her love of extreme sports, tackling daring feats like skydiving, bungee jumping, and climbing to the summit of Mount Kilimanjaro.
Blunt's husband, actor-turned-filmmaker Krasinski, will produce the feature, alongside "American Hustle" writer/director David O. Russell.
According to Deadline.com, a director has yet to be appointed. Neither Krasinski nor Russell are looking to step behind the camera to take charge of the project, which has been adapted for the big screen by Lindsey Ferrentino.
The role helped the Brit pick up her first Screen Actors Guild award in January, when she dedicated the supporting actress prize to her husband, who she praised as a "stunning filmmaker".
"My favourite thing about shooting 'A Quiet Place' was for sure working with John," she later shared. "We'd never done it before, and it is kind of the great unknown, going into this process, not knowing what it's going to be."
"A lot of people were like, 'You're going to be divorced by the end of it', but actually we're so much closer. I think the discovery of how well we collaborated and how well we can create something together is just so special."
They are set to reunite onscreen for a planned sequel, which will also feature the return of their movie kids Millicent Simmonds and Noah Jupe, and is expected to hit theatres in May, 2020.