The actress has landed a guest-starring role as the girlfriend of Johnny Galecki's character, David.
The casting is a little odd as the two former child stars once played brother and sister in 1989 comedy "National Lampoon's Christmas Vacation".
Juliette broke the news on Instagram with a photo of herself seated between castmates Galecki and Sara Gilbert, who is also an executive producer of the new show.
"HERE'S THE BIG NEWS!!," Lewis wrote. "Look what I'm doin!!"
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HERE’S THE BIG NEWS!! Look what I’m doin!!! #LuckyMe #TheConners @theconnersabc #JulietteLewisisonTheConners #whoohoo #GreatWriting #ReunitedWithMyGriswaldBro 😃@sanctionedjohnnygalecki and the incredible @thesaragilbert #JohnGoodman #LaurieMetcalf 🙌🏽🙌🏽 (CAMPING also airs Oct 14th on HBO!!!) #TellYourFriends
Lewis joins another newcomer, Maya Lynne Robinson, on the series, which also features John Goodman, Laurie Metcalf, Lecy Goranson, Michael Fishman, and Emma Kenney reprising roles they played on "Roseanne".
The show, which was revived earlier this year, became a surprise hit, but ABC network bosses cancelled a second season after the sitcom's star Roseanne Barr posted a racially insensitive tweet aimed at one of former U.S. leader Barack Obama's aides.
As a result, the show has been renamed "The Conners" and Roseanne will not be making an appearance. According to her, the character she played has been killed off after suffering a prescription drug overdose.