Anyone who's ever piled into the car dreaming of a great vacation only to drive off into an out-control, disaster-prone, family trip gone south will identify with the outrageous fun and comedy of the JOHNSON FAMILY VACATION. Forget AAA, because even they can't help the roadside emergency that results when Nate Johnson (Cedric the Entertainer) sets out on a cross-country trek from California to Missouri, with three unruly kids and one unsatisfied wife in tow, in order to attend the Johnson clan's annual reunion/grudge match. Not since the Griswolds headed to California, has a family excursion veered so hysterically astray. And yet, even if the Johnsons start out at each other's throats, in the comic adventures ahead they're about to rediscover one another's hearts.
Despite being virtually ignored by his separated wife Dorothy (Vanessa Williams) and out of touch wih his rapper-wanna-be son (Bow Wow), his Lolita-like teenage daughter (Solange Knowles) and his imaginary-dog-toting youngest child (Gabby Soleil), Nate is convinced that he and his relations can make off with the coveted Johnson Reunion Family of the Year award.
But first they have to make it to Missouri. From the minute Nate hits the accelerator of his Lincoln Navigator, the Johnsons encounter one hilarious mishap after another, as they are sucked into the universe of Murphy's Law where anything that can go wrong does... and the catastrophes just keep multiplying. Along the way, Nate is chased by an 18-wheeler out for revenge, savaged by unhygienic diners, put under a spell by a voodoo hitchhiker, taken into police custody for using a biological weapon, set adrift in a corn field and trapped in a hot tub nightmare. Still, nothing can detour Nate from getting his family to Missouri on time except maybe finding Missouri.