Set in the isolated desert of Winslow, Arizona at NASA's Moon Base Simulator, "Moonbase 8" follows eager astronauts Skip (Fred Armisen), Rook (Tim Heidecker) and their leader Cap (John C. Reilly) as they attempt to qualify for their first lunar mission. While working vigorously to complete their training, a series of unexpected circumstances forces the astronauts to question their own mental sanity, trust in each other and whether or not they're cut out for space travel.