While attending an awards banquet, Michael reconnects with his old friend Gene – a photographer who recently found love while abroad in India. When Gene collapses on stage, Michael takes him back to Holt for treatment. As Michael struggles to find the source of Gene's worsening fever, his new girlfriend butts heads with his overbearing but well-meaning mother as both women attempt to comfort the man they love. At the clinic, a young woman with a broken toe reveals that her life was saved by a heart transplant six months ago. While tracking down her medical records, Kate learns something remarkable: the heart used to belong to Anna Paul. When the broken bone causes Fat Embolism Syndrome, a potentially fatal disease, it's up to Michael to rush the patient back to Holt Neuro in order to save her life.