The 38-year-old actress stars as Rebecca Pearson on the hit drama series. She has discussed the challenge of playing a character who is battling Alzheimer's disease as saying, "I don't know if there is a way to brace anybody."
"I wasn't braced for it. I wasn't ready. I had no idea what I was about to read or what we were all going to endeavor to do," she continued. "I didn't know how [series creator] Dan [Fogelman] was going to flesh out the end."
The actress said that she believes there's something "surprising" about the storyline. She told Entertainment Weekly, "I would encourage people to come in with an open mind, and I'm sure they know where this is heading, but I think it's surprising. I imagine that this is [a] very real way for some people to imagine the end of their life."
Meanwhile, Milo Ventimiglia previously described Mandy as the "best" on-screen partner he's ever had. The 44-year-old actor, who plays Jack Pearson on "This Is Us", also hailed the actress' "commitment" and "dedication" to her work.
"I've got to say she has been probably in my 26 years in front of the camera, the best partner I've ever had, her commitment, her dedication, her growth as an artist," he explained. "The audience, you guys get to watch the show in its entirety. I get to sit there in front of her, or stand in front of her, or lay in a bed next to her and watch front row what she does and how impactful it is, the work is to her. And I've only seen it grown. So, it's been a pleasure to be her TV husband for six years."
Milo then concluded, "At the same time, closing this chapter, I'm very excited to see what Mandy does next because she's such a force."