The married actors are currently having their property renovated, but a new paint job on the exterior of the building was destroyed on Monday (05Jul21) after the suspect allegedly used orange paint to decorate the walls with his social media handles and messages to the "Modern Family" beauty Vergara, who he believes is his mother.
According to TMZ, the man was still on site when police arrived and questioned him about his actions, which the perpetrator apparently revealed had just been completed.
The cost of the damage caused is reported to be over $100,000 (£72,000).
The stars were not present at the time, but Manganiello later appeared on the scene to talk to authorities, who took the suspect into custody.
Representatives for the couple have yet to comment on the incident.
The incident happened roughly eight months after Sofia Vergara and Joe Manganiello were granted a restraining order against an obsessed fan.
Rengifo Randazzo was arrested last year for trespassing in the gated community where the actress lives. He also allegedly harassed her husband Joe and son Manolo.
Sofia and Joe have been married since 2015. She was previously engaged to Nick Loeb. Their separation led to a longtime legal battle over the rights to their frozen embryos.
Nick wanted to use a surrogate to bring the fertilised eggs to term, but Sofia objected. After multiple attempts, he eventually lost in final appeal earlier this year.