The 36-year-old Oscar winner fronted director Jordan Peele's horror movie, which has become one of the 2019's biggest releases, and gossip about a follow-up has been rampant in recent weeks.
But, even though Lupita is getting awards buzz for her performance as Adelaide Wilson and twisted doppelganger Red, she insists she has no interest in reprising the role.
"No thanks. Red is dead," Lupita said during an appearance on Deadline's latest Contenders interview, adding she is not interested in reprising her duel roles as they were "very challenging".
"I had to hold down both sides of the argument," she explained. "I had to be the offender and the offended. It was about understanding the emotional landscape of each character but also having a very strict discipline to play both physically and mentally."
Although the star has no interest in working on a sequel movie, earlier this year she recreated her creepy character to scare film fans at Universal Studios' Halloween Horror Nights in Los Angeles in an Us-themed maze attraction.