According to TV Line, the 60-year-old actress, who stars as Karen on the NBC sitcom, recently took a temporary leave of absence from filming of the final season.
While the reason for the break remains unknown, it comes amid reports of an ongoing feud between Megan and her co-star Debra Messing, who plays Karen's pal Grace in the show.
Debra and Megan had stopped following each other on Instagram, according to fans. And when Debra uploaded a picture to Instagram of the cast without Megan, it further fuelled rumours of a feud, prompting some to speculate that's why the show was coming to an end.
However, Eric McCormack, who plays Will in the show, labelled the reports "crazy," telling Us Weekly: "I think people worried about that entirely too much."
The 11th and final season of "Will & Grace" is set to debut early next year.