Studio Paramount announced it was cancelling the event, due to take place in the Westwood neighbourhood of Los Angeles on Sunday, November 11, as it would be affected by the spreading Woolsey Canyon fire.
"In light of the ongoing, active fires being battled in the area, we have cancelled tomorrow's red carpet and after-party of the Los Angeles premiere of Instant Family. We will move forward with the screening, as a number of foster youths and organisations working in the foster community will be in attendance," a statement from Paramount read.
"Food intended for the after-party will be donated to The American Red Cross, which is providing aid to victims of the fires."
Paramount also added that they would be screening the film at an evacuation centre for victims of the fires.
Octavia took to Twitter to lend her support to the brave firefighters tackling the deadly blaze.
"Sending up prayers to all of you on the frontlines battling fires all across California. Praying for those whose homes are in harm's way and those who have lost everything. Please donate..." she shared.
Sending up prayers to all of you on the frontlines battling fires all across California. Praying for those whose homes are in harm’s way and those who have lost everything. Please donate… https://t.co/cD374Uf44V— octavia spencer (@octaviaspencer) November 11, 2018
The Woolsey Canyon fire erupted on Thursday in Ventura County, and has since spread to 70,000 acres.
At least 25 people have died in the wildfires across northern and southern California, with more than 250,000 people evacuated from their homes.