Set in East Texas in the early 20th century, the story centers on a young man named Jack (Charlie Plummer), who goes on a quest to rescue his sister after she has been kidnapped by a violent killer "Cut Throat Bill" (Noomi Rapace) and her gang. He enlists the help of a crafty bounty hunter named Shorty (Peter Dinklage), a grave-digging alcoholic son of an ex-slave and a street-smart prostitute to help him on his mission.