Eubanks (Danny Glover), an old-school pig farmer from Georgia on the brink of losing his family farm, sets off on a road trip with Howard, his beloved and very large pig. As they make their way across the border to Mexico to find 'Howie' a new home, Eubanks' drinking and deteriorating health begin to take a toll, derailing their plans.

His estranged daughter, Eunice (Maya Rudolph), is forced to join them on their adventure. Driven by strong convictions and stubbornness in his old ways, Eubanks attempts to make peace through his devotion to Howie and desire to mend his broken relationships.