"Jane Wants a Boyfriend" centers around Jane-a bright-eyed young woman in her mid 20s living with autism-and her overprotective, and recently engaged, older sister Bianca. When their parents announce that they are moving out of their Brooklyn brownstone and heading to the suburbs of New Jersey, they propose the sisters move in together-a suggestion that throws Bianca's newly engaged life through a loop and forces her to re-examine her relationship with her sister.